Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5

Product Properties

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5

CAS NO.:4290-13-5

MF: C₁₅H₂₀O₃
MW: 248.317505
Appearance:White Fine Power
Detection Method: HPLC
Purity: 99%
EINECS NO.: 4290-13-5

Packing & Delivery

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5
CAS NO.:4290-13-5

Package: 125ml Sample Package; 1L Standard Package;500ml,1L/Bottle; 5L,10L/Drum; 15L,20L/Carton; or according to customers' requirement.
Storage: Store in cool & dry place. Keep away from strong light and heat.

Delivery: 1-2 working days after payment/FedEx, DHL, TNT, EMS, etc.

Detailed Description

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5
CAS NO.:4290-13-5

Saussurea lappa C.B. Clarke (Compositae) is indigenous to India and Pakistan. The dried root of S. lappa has been traditionally used for alleviating pain in abdominal distention and tenesmus, indigestion with anorexia, dysentery, nausea, and vomiting. Santamarin is a sesquiterpene lactone isolated from S. lappa. In the present study, santamarin inhibited inducible nitric oxide synthase (iNOS) protein, reduced iNOS-derived nitric oxide (NO), suppressed COX-2 protein and reduced COX-derived PGE(2) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and murine peritoneal macrophages. Similarly, santamarin reduced tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production. In addition, santamarin suppressed the phosphorylation and degradation of IκB-α as well as the nuclear translocation of p65 in response to LPS in RAW264.7 cells. Furthermore, santamarin induced heme oxygenase (HO)-1 expression mRNA and protein level that plays a cytoprotective role against inflammation. The induction of HO-1 is primarily regulated at the transcriptional level, and its induction by various agents is mediated by the nuclear transcription factor E2-related factor 2 (Nrf2), master regulator of antioxidant responses. Unbound Nrf2 translocates into the nucleus and binds to the antioxidant response element (ARE) in the upstream promoter region of many antioxidative genes, where it initiates their transcription. The effects of santamarin on LPS-induced NO, PGE(2), TNF-α, and IL-1β production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Therefore, our data suggest that the anti-inflammatory effect of santamarin in macrophages may be exerted through a novel mechanism that involves HO-1 expression.

Functions

Applications

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5
CAS NO.:4290-13-5

Santamarine and 9beta-acetoxycostunolide inhibited L1210 cell growth, colony formation and [(3)H]-thymidine incorporation in time- and concentration-dependent manners. Flow cytometry studies showed that Santamarine and 9beta-acetoxycostunolide blocked L1210 cells in the G(2)/M phase of the cell cycle. DAPI staining and caspase activity assays showed Santamarine and 9beta-acetoxycostunolide induced apoptosis and activated caspase 3 in L1210 cells. CONCLUSIONS: These results indicated that Santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide exhibit significant anticancer activities in vitro. The inhibitory effects of Santamarine and 9beta-acetoxycostunolide on L1210 cells are cytotoxic rather than just cytostatic. They block mitosis and reduce uptake of thymidine. The mechanism of the cytotoxicity of Santamarine and 9beta-acetoxycostunolide to L1210 cells could be related to alkylation of the sulfhydryl enzymes involved in nucleic acids and protein synthesis, as previously found for other sesquiterpenes with the alpha-methylene-gamma-lactone moiety present in Santamarine, 9beta-acetoxycostunolide and 9beta-acetoxyparthenolide. It may also be related to suppression of microtubular proteins. Santamarine and 9beta-acetoxycostunolide induced apoptosis of L1210 cells via activation of caspase 3.

Company Profile

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5
CAS NO.:4290-13-5

Shaanxi Baisfu Biological Co., Ltd. was founded in 2008, is a technological export-oriented private enterprise with the Rights of Self-Managed Import and Export, specializing in active ingredients modernized and industrialization research, development, production, and sales of natural medical botany.

Our factory covers an area of 6,000 square meters equipped with advanced equipment and the production process is in accordance with FDA.

Since its inception, the company is aiming at providing every customer with top best quality products and superior service at a reasonable and competitive price, all the time. And in the past 9 years, we’ve gained great progress.

Our products are exported to countries all over the world: USA, countries in North America, South America, European countries like UK, Germany, Sweden, Greece, Finland, Norway, France, Italy, Russia, Ukraine, Estonia, Spain, Latvia, etc. Asia countries like Malaysia, Indonesia, South Korea, Thailand, Philippines, Vietnam, Singapore, etc. Our products are selling very well in these areas. And other countries like Australia, Mexico, Salvatore, Costa Rica, and so on. What’s more, for the high quality products and superior service we provide, we’ve been highly appreciated by our customers. We are getting more and more returning customer day by day.

& Our Company always persist in:

Top Quality Products, Excellent Professional Knowledge, Superior Service

How to Order

Baisfu White Fine Power Hot Selling High Quality Santamarin CAS NO.4290-13-5
CAS NO.:4290-13-5

1. Make sure your quantity need and Leave us message, with your mailed details shown: Including contact name, address information, contact phone, etc.
2. We send you a PI (Proforma Invoice) for price and payment detail.
3. Payment by Paypal or Western Union or T/T.
4. We arrange the delivery and update you the tracking number in time.

FAQ

Santamarin
CAS NO.:4290-13-5

Q1: Could you provide free sample for test?
A1: We can provide you free sample for test, and you only need to pay the delivery cost.

Q2: Which payment terms do you accept?
A2: PayPal, T/T, West Union, Bank Transfer, etc.

Q3: What's about the MOQ ?
A3: It depends on different products. Usually our MOQ is 5kg.

Q4: What’s the delivery lead time?
A4: We will make delivery within 1-2 days after receiving payment.

Q5: What about the delivery port?
A5: Main ports in China are available (Hong Kong,Guangzhou,Shenzhen).