Product Properties
Ranaconitine
CAS No.: 1360-76-5
20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-4,7,8,9-TETROL4-[2-(ACETYLAMINO)BENZOATE];
4-[2-(ACETYLAMINO)BENZOYLOXY]-20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-7,8,9-TRIOL; O4-(2-ACETAMIDOBENZOYL)RANACONINE;
(1ALPHA,14ALPHA,16BETA)-ACONITANE-4,7,8,9-TETROL20-ETHYL-1,14,16-TRIMETHOXY-4-[2-(ACETYLAMINO)BENZOATE];
7-HYDROXYLAPPACONITINE;
Product Name:Ranaconitine
Latin Name: Aconitum sinomontanum Nakai
Chemical Name: 20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-4,7,8,9-TETROL4-[2-(ACETYLAMINO)BENZOATE];
4-[2-(ACETYLAMINO)BENZOYLOXY]-20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-7,8,9-TRIOL; O4-(2-ACETAMIDOBENZOYL)RANACONINE;
(1ALPHA,14ALPHA,16BETA)-ACONITANE-4,7,8,9-TETROL20-ETHYL-1,14,16-TRIMETHOXY-4-[2-(ACETYLAMINO)BENZOATE];
7-HYDROXYLAPPACONITINE;
Appearance: Colorless needle crystal
CAS No.: 1360-76-5
MF: C32H44N2O9 MW: 600.705
Active Ingredient: Ranaconitine
Source: The root of the herbaceous plant, Aconitum sinomontanum Nakai, belongs to diterpenoid alkaloid
Detection Method: HPLC/UV
Purity:≥ 98% Density?1.39
Melting Point: 132-134?
Water Solubility: Insoluble in water, soluble in ethanol, Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetoneetc?etc.
Shelf Life: 2 Years
Shaanxi Baisfu Bioengineering Co., Ltd. is an enterprise specializing in the research and development, production and sales of flavors and fragrances. The company is located in Building A, Baodeyun Valley, No. 52, Jinye 1st Road, Yanta District, Xi'an City, Shaanxi Province. It has an excellent geographical location and convenient transportation. convenient. The company was established in December 2019, with a registered capital of 3 million yuan.
The company's main products include cooling agents, synthetic flavors and natural flavors. The company's products can be used in food and beverage, daily chemical, and other industries, and have a wide range of downstream applications.
The company always attaches great importance to product quality and brand reputation, strictly implements product quality and environmental management control, and has passed various certifications such as GPM, ISO9001, ISO14001, kosher, and HALAL European analysis.
The company's products are used by more than 30 foreign companies and regions. After more than ten years of technology accumulation and market development, the company has accumulated a group of high-quality customer groups, stable customer channels and resources, and has established relationships with more than 100 domestic and foreign companies. Good working relations.
effect
Packing & Delivery
Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers' requirement.
Storage: Store in cool & dry place. Keep away from strong light and heat.
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Detailed Description
Ranaconitine
CAS No.: 1360-76-5
20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-4,7,8,9-TETROL4-[2-(ACETYLAMINO)BENZOATE];
4-[2-(ACETYLAMINO)BENZOYLOXY]-20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-7,8,9-TRIOL; O4-(2-ACETAMIDOBENZOYL)RANACONINE;
(1ALPHA,14ALPHA,16BETA)-ACONITANE-4,7,8,9-TETROL20-ETHYL-1,14,16-TRIMETHOXY-4-[2-(ACETYLAMINO)BENZOATE];
7-HYDROXYLAPPACONITINE;
Aconitum leucostomum Worosch is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM. The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine , N-deacetyllappaconitine , and Ranaconitine , and two C19-diterpene alkaloids, delvestidine and anthranoyllycoctonine, were isolated from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was ranked as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>Ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine and anthranoyllycoctonine being the two most toxic compounds to cardiomyocytes in our assays. These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.
Applications
Ranaconitine
CAS No.: 1360-76-5
20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-4,7,8,9-TETROL4-[2-(ACETYLAMINO)BENZOATE];
4-[2-(ACETYLAMINO)BENZOYLOXY]-20-ETHYL-1α,14α,16β-TRIMETHOXYACONITANE-7,8,9-TRIOL; O4-(2-ACETAMIDOBENZOYL)RANACONINE;
(1ALPHA,14ALPHA,16BETA)-ACONITANE-4,7,8,9-TETROL20-ETHYL-1,14,16-TRIMETHOXY-4-[2-(ACETYLAMINO)BENZOATE];
7-HYDROXYLAPPACONITINE;
1. Applied in agriculture field, as a natural plant pesticides that once touched the drug will suffocate;
2. Applied in pharmaceutical field, matrine injection on the treatment of chronic persistent hepatitis have a good effect; can treat trichomonas vaginitis
3. Applied in cosmetic field, it has good effect of anti-acne.
(1) Pharmaceutical as capsules or pills;
(2) Functional food as capsules or pills;
(3) Water-soluble beverages;
(4) Health products as capsules or pills.
Aconitum leucostomum Worosch is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM. The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine , N-deacetyllappaconitine , and Ranaconitine , and two C19-diterpene alkaloids, delvestidine and anthranoyllycoctonine, were isolated from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was ranked as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>Ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine and anthranoyllycoctonine being the two most toxic compounds to cardiomyocytes in our assays. These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.
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